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This is the preliminary program for the 2006 Joint Statistical Meetings in Seattle, Washington.

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Activity Number: 63
Type: Contributed
Date/Time: Sunday, August 6, 2006 : 4:00 PM to 5:50 PM
Sponsor: Biometrics Section
Abstract - #307535
Title: Detecting Cerebral Activation from Functional Magnetic Resonance Imaging Data
Author(s): William Baumann*+ and Ranjan Maitra
Companies: Iowa State University and Iowa State University
Address: 1405 Maxwell Ave., Ames, IA, 50010,
Keywords:
Abstract:

Functional Magnetic Resonance Imaging (fMRI) is a non-invasive radiologic tool used to detect activity in the human brain. An usual approach is to perform hypothesis-testing on a general linear model which fits the time-course sequence at a voxel to the input sequence. Multiple comparisons are then used to identify activation regions. We propose, instead, an estimation approach which fits a mixture model to the distribution of the p-value at each voxel. Mixing proportions and the parameters of the non-central t-density are estimated in a hierarchical setting which incorporates spatial context. These are then used to identify regions of activated voxels with high probability.


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Revised April, 2006