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Activity Number: 430
Type: Luncheons
Date/Time: Wednesday, August 9, 2006 : 12:30 PM to 1:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #307514
Title: Interval Censored Time-to-Event Data: Examples, Analyses, and Assumptions
Author(s): Daohai Yu*+
Companies: Duke University
Address: 406 Somersview Drive, Chapel Hill, NC, 27514,
Keywords: interval censoring ; conditional model ; dependent censoring ; discretionary visits ; serial screening ; survival analysis
Abstract:

The random censorship assumption is violated often in interval censored (IC) time-to-event data, such as when the data arise from a serial screening and the timing of screening potentially could depend on the patient's health status. Some examples of dependent IC event data will be discussed, along with data analysis methods currently available for IC time-to-event data. Underlying assumptions for each method will be examined and compared. In particular, a new likelihood-based approach coupled with a class of innovative conditional models for dependent, interval-censored, time-to-event data with a marker for discretionary visits will be discussed and compared with the current analysis methods assuming independent censoring.


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