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Activity Number:
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421
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Type:
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Contributed
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Date/Time:
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Wednesday, August 9, 2006 : 10:30 AM to 12:20 PM
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Sponsor:
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Biometrics Section
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| Abstract - #307482 |
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Title:
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Functional Mapping of Time-Warped Developmental Trajectories Based on B-Splines
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Author(s):
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Xueli Liu*+ and Rongling Wu
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Companies:
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University of Florida and University of Florida
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Address:
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Department of Statistics , Gainesville, FL, 32611,
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Keywords:
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alignment ; b-splines ; functional mapping ; nonparametric function estimation ; quantitative trait loci (QTL) ; time-warping
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Abstract:
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Dynamic quantitative traits whose phenotypic values change with time are of economic, biological and clinical importance. When the dynamics of development over time are at issue, subjects may experience events at a different temporal pace, which may be under genetic control. Previous genetic mapping of quantitative trait loci underlying dynamic traits has typically not been based on a model in which trajectories may be individually time-transformed. We propose an innovative model framework where we consider subjecting each trajectory to a time transformation in an attempt to reverse the warping of the time scale. Our model assumes a monotone time transformation for each trajectory. Subjects are aligned and the alignment helps to estimate the positions and effects of multiple QTL. The method is demonstrated and validated by simulated studies.
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