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Activity Number: 25
Type: Contributed
Date/Time: Sunday, August 6, 2006 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #307432
Title: On O'Brien's OLS and GLS Tests for Multiple Endpoints
Author(s): Sergei Leonov*+ and James Roger and Nigel Dallow
Companies: GlaxoSmithKline and GlaxoSmithKline and GlaxoSmithKline
Address: 1250 S. Collegeville Road, Collegeville, PA, 19426,
Keywords: multiple endpoints ; O'Brien's OLS and GLS tests ; operational effect size ; sample size calculation ; adjustment for covariates
Abstract:

O'Brien (1984) proposed two global multivariate tests, OLS and GLS, to compare two treatment groups on multiple endpoints. In this presentation the term "operational effect size", or OES, is introduced, which is the effect size that would be required for a single endpoint to have the same power in an equivalently sized study. We mention the fundamental inequality between OES for GLS and OLS tests which explains why the GLS test is generally more powerful than the OLS test. We explore the effect of different correlation structures and discuss the adjustment of both tests for covariates.

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