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Activity Number: 64
Type: Contributed
Date/Time: Sunday, August 6, 2006 : 4:00 PM to 5:50 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #307398
Title: Pedigree Disequilibrium Test for X-Chromosome Markers
Author(s): Jie Ding*+ and Shili Lin
Companies: The Ohio State University and The Ohio State University
Address: Department of Statistics, Columbus, OH, 43210,
Keywords: association test ; x-chromosome ; missing genotypes ; Monte Carlo
Abstract:

Because of the need for fine mapping of disease susceptibility loci and the availability of dense genetic markers, many forms of association tests have been developed. Some of them only apply to nuclear families and some of them can not handle missing genotypes. Here, we extended the pedigree disequilibrium test (PDT) to marker loci on X-chromosome. Furthermore, we treated families with missing genotypes by averaging over a Monte Carlo sample of those genotypes, which are generated conditioning on known genotypes. Association test based on haplotypes can also be carried out in this framework. The method was compared to existing approaches through simulation, and was applied to analyze a multiple sclerosis dataset.

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