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Activity Number:
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154
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Type:
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Contributed
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Date/Time:
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Monday, August 7, 2006 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #307284 |
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Title:
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Dynamic Treatment Allocation and Randomization Tests in Clinical Trials
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Author(s):
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Lee-Lian Kim*+ and Yaung-Kaung Shen and Jewel Johanns and Aparna Raychaudhuri
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Companies:
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Centocor R&D, Inc. and Centocor R&D, Inc. and Centocor R&D, Inc. and Centocor R&D, Inc.
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Address:
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200 Great Valley Parkway, Malvern, PA, 19355,
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Keywords:
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randomization tests ; dynamic treatment allocation ; SAS
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Abstract:
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There are different methods to randomize subjects to treatment arms in a clinical trial. One method used is dynamic treatment allocation. Here, the treatment allocated to a subject depends on the distribution of subjects that had been randomized previously. It has been noted by the European Agency for the Evaluation of Medicinal Drugs (EMEA) that if a clinical trial utilizes dynamic treatment allocation to randomize subjects to the treatment arms of the clinical study, randomization tests would be the proper tool to account for the dynamic treatment allocation. In this presentation, we describe the method to perform randomization tests in SAS for categorical data. This can also be expanded to continuous data.
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