A Genome-Wide Study on Transcriptional Regulation of Protein Complex in Saccharomyces Cerevisiae

• Activity Number: 427
• Type: Contributed
• Date/Time: Wednesday, August 9, 2006 : 10:30 AM to 12:20 PM
• Sponsor: Biometrics Section
• Author(s): Ching-Ti Liu*+ and Shinsheng Yuan and Ker-Chau Li
• Companies: University of California, Los Angeles and University of California, Los Angeles and University of California, Los Angeles
• Keywords: protein complex ; protein-protein interaction ; microarray expression data

Abstract

Characterization of protein-protein interaction has become a key step in understanding the cellular mechanism because most biological processes cannot be carried out without protein-protein interaction. This presentation will focus on a set of well-validated protein complex data from MIPS. It is commonly believed that functionally related genes tend to have similar patterns of variation in expression. However, we found notable contradictory evidence. Indeed, except for a few large protein complexes such as cytoplasmic or mitochondrial ribosomal proteins, the co-expression level of genes from the same complex is on the average not much higher than that from a pair of randomly selected genes. We find this result to be true for four well-known gene expression datasets. We also study ways of incorporating the ChIP-on-Chip data for protein complexes analysis.