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Activity Number:
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426
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Type:
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Contributed
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Date/Time:
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Wednesday, August 9, 2006 : 10:30 AM to 12:20 PM
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Sponsor:
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Biometrics Section
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| Abstract - #307223 |
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Title:
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Including Current Ages in Aggregation and Linkage Analysis of Longevity
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Author(s):
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Jeanine Houwing-Duistermaat*+ and Andrea Callegaro and Marian Beekman and Rudi Westendorp and Eline Slagboom and Hans van Houwelingen
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Companies:
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Leiden University Medical Center and Leiden University Medical Center and Leiden University Medical Center and Leiden University Medical Center and Leiden University Medical Center and Leiden University Medical Center
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Address:
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P.O. Box 9600, Leiden, 2300 RC, The Netherlands
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Keywords:
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longevity ; excess survival ; linkage analysis
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Abstract:
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Dutch long-lived sibling pairs both older than 90 years from 100 families have been collected and genotyped for 6 microsatellite markers in a candidate region. Current age or age at death are available for the parents and siblings of the nonagenarain siblings. The standard mortality ratio using survival data for the Dutch population can be used to measure excess survival. Standard affected sibling pair linkage analysis can be used to analyze the genetic markers. We propose to extend these methods and include also information on the current ages of the siblings. To assess if the excess survival depends on the current ages of the long lived siblings, we used a Poisson model with as covariate a score based on the ages of the long-lived sib-pairs, namely the martingale residuals. For linkage analysis we propose a robust Haseman-Elston method also based on the martingale residuals.
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