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Activity Number:
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548
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Type:
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Contributed
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Date/Time:
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Thursday, August 10, 2006 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #307218 |
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Title:
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Comparison of Two Step-Down Linear Trend Tests
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Author(s):
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Kaifeng Lu*+
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Companies:
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Merck & Co., Inc.
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Address:
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126 E. Lincoln Avenue, Rahway, NJ, 07065,
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Keywords:
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closed testing principle ; power ; step-down
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Abstract:
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In dose ranging studies, treatments are usually composed of placebo and a series of increasing doses of active drug. Researchers are often interested in testing for linear trend in the response curve and identifying the maximum dose concentration of the active drug which is not significantly different from placebo. This talk discusses a class of step-down testing procedures which conform to the closed testing principle. The power and type 1 error rate for two commonly used step-down linear trend tests are compared. The alternative hypotheses at which the two step-down testing procedures are targeted are identified. Simulation studies are carried out to assess the performance of the two step-down testing procedures. Extensions to discrete responses are also discussed.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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