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Activity Number: 64
Type: Contributed
Date/Time: Sunday, August 6, 2006 : 4:00 PM to 5:50 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #307144
Title: Incorporating Endophenotypes into Allelic Association Studies
Author(s): Chao Hsiung*+
Companies: National Health Research Institutes
Address: 35 Keyan Road, Zhunan Miaoli, 350, Taiwan
Keywords: endophenotype ; concordant sibpair ; discordant sibpair ; association study
Abstract:

For a genetic study in which there are concordant and discordant sibships for a complex disease trait and there are also available the measurements of other endophenotypes for each of the individuals, we describe a test for association that utilizes nonparametrically the additional endophenotypes. Data from the Stanford Asian Pacific Program in Hypertension and Insulin Resistance (SAPPHIRe) are used to illustrate the method.

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