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Activity Number:
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161
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Type:
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Luncheons
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Date/Time:
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Monday, August 7, 2006 : 12:30 PM to 1:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #307136 |
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Title:
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Time-to-Event Analysis with Uncertain Endpoints
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Author(s):
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Li Chen*+
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Companies:
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Amgen Inc.
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Address:
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One Amgen Center Drive, Thousand Oaks, CA, 91320,
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Keywords:
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Abstract:
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Time-to-event analysis of nonfatal endpoints or fatal events due to certain causes often involves classification of the endpoints as true or false according to decision rules. If these endpoints are not obvious to decipher whether true or false, they exhibit a level of uncertainty. Typically, only the endpoints confirmed as true events by an endpoint committee are used in the analysis. Information contained in the level of certainty is lost. Snapinn (1998) proposed a weighted Cox regression model that allows all potential endpoints to be included in the analysis, along with the level of certainty of each. This session will discuss the benefit of the method, recent development of the method, and its application in clinical trials.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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