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Activity Number: 138
Type: Topic Contributed
Date/Time: Monday, August 7, 2006 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract - #307101
Title: An Application of Propensity Score Method in Medical Device Trials
Author(s): Minglei Liu*+ and Jianming Wang and Jane Gau
Companies: Medtronic, Inc. and Medtronic, Inc. and Medtronic, Inc.
Address: Medtronic Vascular, Santa Rosa, CA, 95403,
Keywords: propensity score ; imputation ; treatment effect
Abstract:

Propensity score method is a useful tool to adjust the selection bias and accurately estimate treatment effects. While it is used widely in all kinds of clinical trials, there is no general rule about how the subgroup (quintiles) should be combined. We will discuss how this is applied in a case study in medical device clinical trials, including missing value imputation, score calculation, subgroup analysis, and the combination method.


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