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Activity Number: 293
Type: Contributed
Date/Time: Tuesday, August 8, 2006 : 10:30 AM to 12:20 PM
Sponsor: WNAR
Abstract - #306976
Title: Examining the Multiple Dye-Swap Design for Efficient and Effective Microarray Studies
Author(s): Theresa Kim*+
Companies: University of Washington
Address: Department of Biostatistics, Seattle, WA, 98195,
Keywords: experimental design ; gene expression ; microarray
Abstract:

For 2-group comparison microarray experiments with biological replicates, Kerr (Biometrics, 2003) showed that a multiple dye-swap strategy is a very efficient, practical design. For more than two groups, the design extends naturally, but there is more than one generalization when there are four or more groups. We explore different options for the extension of the multiple dye-swap design for 3, 4, 5, and more groups and evaluate these options in terms of their efficiency for making pairwise group comparisons.


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