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Abstract:
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In monitoring a clinical trial or other observational study with survival endpoint, sometimes the numbers of patients entering and dying at each time point might be presented, but the connections between them were kept confidential. Hence the exact time to failure or censoring for each individual was missing. We refer to such a "study monitoring table" with missing pairing information between the entry and death times as "broken" survival data. In this paper we study the problem of estimating the survival distribution from a broken survival data set. We have developed two methods, likelihood-based estimation and self-consistency estimation, to estimate the survival curve parametrically and empirically, respectively. We use simulations to study the properties of these methods, and illustrate them with data from the STELLAR-3 trial.
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