Biomarker Analysis of Medical Imaging and Radiotelemetry Signals

• Activity Number: 368
• Type: Topic Contributed
• Date/Time: Wednesday, August 9, 2006 : 8:30 AM to 10:20 AM
• Sponsor: Biopharmaceutical Section
• Author(s): Christopher Tong*+ and Yevgen Tymofyeyev and Karim Azer and Philip E. Brandish and Hongxing Chen and James C. Hershey and Matthew Walker, III and Barry R. Campbell and Kaijie Fang and Donald S. Williams and Alexandre Coimbra
• Companies: Merck Research Laboratories and Merck Research Laboratories and Merck Research Laboratories and Merck Research Laboratories and Merck Research Laboratories and Merck Research Laboratories and Merck Research Laboratories and Merck Research Laboratories and Merck Research Laboratories and Merck Research Laboratories and Merck Research Laboratories
• Keywords: biomarkers ; radiotelemetry ; medical imaging

Abstract

In this talk, we focus exclusively on quantitative biomarkers that are measured in animal models of diseases. Biomarkers from medical imaging modalities---such as ultrasound, magnetic resonance imaging (MRI), and functional MRI---and radiotelemetry signals are discussed in the context of cardiovascular, neurological, and bone diseases. These biomarkers are in vivo measurements that allow for longitudinal tracking of structural and/or functional changes with disease progression. In some situations, a biomarker must be selected from a set of plausible candidates; in others, our understanding of the physiological processes and the nature of the measurement technology allows us to formulate a potential biomarker we will evaluate. Statistical challenges are discussed, including hierarchical models and problems of large-scale time-series data.