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Activity Number:
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409
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Type:
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Topic Contributed
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Date/Time:
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Wednesday, August 9, 2006 : 10:30 AM to 12:20 PM
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Sponsor:
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IMS
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| Abstract - #306764 |
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Title:
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A Random Duplication/Deletion Model in Genome Rearrangement
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Author(s):
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Soowan Sohn*+ and Bret Larget
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Companies:
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University of Wisconsin-Madison and University of Wisconsin-Madison
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Address:
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1300 University Ave., Madison, WI, 53706,
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Keywords:
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Abstract:
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Variation in the arrangements of genomes is an alternative source of information for estimating evolutionary relationships among species. Existing statistical approaches for the analysis of genome arrangement data are based on the mechanism of gene inversion to rearrange genomes. However, the molecular evolution literature suggests a process of gene duplication and subsequent deletion is an important mechanism for genome rearrangement. We develop a model for gene duplication/deletion in which a set of neighboring genes is duplicated before one of the two copies of each gene, selected at random, is deleted. This process is related to a card-shuffling model. We develop a Bayesian method to infer a phylogeny under a gene duplication/deletion model for genome rearrangement. We use the Markov chain Monte Carlo Method to compute posterior probabilities.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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