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Activity Number:
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136
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Type:
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Topic Contributed
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Date/Time:
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Monday, August 7, 2006 : 10:30 AM to 12:20 PM
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Sponsor:
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Section on Statistics in Epidemiology
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| Abstract - #306751 |
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Title:
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The McDonald-Kreitman Test in Studies of Molecular Evolution
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Author(s):
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Jason Gardenier*+
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Companies:
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The College of William & Mary
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Address:
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115 Saint Andrews Drive, NE, Vienna, VA, 22180,
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Keywords:
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molecular evolution ; Mcdonald-Kreitman ; MK-test ; DNA sequencing
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Abstract:
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The purpose of this presentation is to demonstrate how the McDonald-Kreitman (MK) test is being used to clarify the driving force of molecular evolution. By comparing the ratios of salient versus replacement substitutions between two species and within species, one can use the G-test of statistical significance to test the Neutral Theory of Molecular Evolution. As the speed with which DNA can be sequenced has been increasing rapidly, the need to have exact readings of nucleotides has become critical. The MK test is being used more often to elucidate the relative importance of Darwinian natural selection versus neutral genetic drift in driving overall evolution.
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