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Activity Number:
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287
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Type:
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Contributed
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Date/Time:
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Tuesday, August 8, 2006 : 10:30 AM to 12:20 PM
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Sponsor:
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Biometrics Section
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| Abstract - #306668 |
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Title:
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Application of Pharmacokinetic Modeling To Guide Clinical Sample Testing
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Author(s):
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Andrew Chen*+ and Harry Yang and Lanju Zhang and Iksung Cho and Ed O'Connor
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Companies:
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MedImmune, Inc. and MedImmune, Inc. and MedImmune, Inc. and MedImmune, Inc. and MedImmune, Inc.
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Address:
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One MedImmune Way, Gaithersburg, MD, 20878,
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Keywords:
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pharmacokinetic modeling ; dilution ; clinical testing
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Abstract:
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In clinical testing, it is a common practice to perform an initial dilution of a test sample to increase the probability that the final test result will be in a quantifiable range of the assay. However, choosing an optimal starting dilution is not always straightforward. The absence of proper methods guiding the starting dilution often results in repeated testing of the same sample, and increases the overall cost of testing. In this paper, we introduce a multiple dosing pharmacokinetic model that can be used to optimize the choice of initial dilution. The model parameters were estimated based on a single-dose study. This model allows us to customize the initial dilution scheme for each individual sample. A simulation study showed the model effectively reduced the amount of repeated testing.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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