Antioxidant Use Predicts Transitions to Amnestic MCI and Dementia

• Activity Number: 76
• Type: Contributed
• Date/Time: Sunday, August 6, 2006 : 8:00 PM to 9:50 PM
• Sponsor: ENAR
• Author(s): Marta Mendiondo*+ and Richard J. Kryscio and Fred A. Schmitt
• Companies: University of Kentucky and University of Kentucky and University of Kentucky
• Keywords: mild cognitive impairment ; Alzheimer's disease ; Markov chain ; shared random effects ; polytomous logistic regression ; risk factors

Abstract

The effect of antioxidants on transitions from normal to dementia is unknown. We examined the annual cognitive tests from the BRAINS cohort, a group of 785 initially cognitively normal subjects followed at the University of Kentucky Alzheimer's Disease Center. Subjects have an average of 8 assessments. Subjects were placed into one of three transient states at each assessment: cognitively normal, amnestic mild cognitive impairment (MCI), mixed MCI. Conversion to dementia or death are considered absorbing states. A multi-state Markov chain based on a shared random effects polytomous logistic regression model was used to model transitions among states. After controlling for age, gender, education, family history of dementia, and the presence of an APOE 4 allele, baseline antioxidant use predicts transitions from normal to amnestic MCI and from amnestic MCI to dementia.