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Activity Number: 469
Type: Contributed
Date/Time: Wednesday, August 9, 2006 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #306530
Title: Assessing the Superiority of a Combination Drug
Author(s): Jianjun Li and Steven Snapinn and Guoyong Jiang*+
Companies: Merck Research Laboratories and Amgen Inc. and Cephalon, Inc.
Address: 41 Moores Road, Frazer, PA, 19355,
Keywords: composite hypothesis ; min test ; nonmonotone test
Abstract:

We propose new tests for evaluating the superiority of a combination drug by modifying the critical value of the conservative min test. The critical values of these new tests are determined as continuous functions of the observed difference between the component effects. This approach offsets the conservativeness of the min test, resulting in a sizable improvement in power while maintaining the type-I error rate. Two real data examples are presented for illustration.

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