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Activity Number: 386
Type: Contributed
Date/Time: Wednesday, August 9, 2006 : 8:30 AM to 10:20 AM
Sponsor: Section on Bayesian Statistical Science
Abstract - #306528
Title: Bayesian Clustering of SNP Genotypes
Author(s): Guohua Yan*+ and William J. Welch and Ruben H. Zamar
Companies: The University of British Columbia and The University of British Columbia and The University of British Columbia
Address: 333-6356 Agricultural Road, Vancouver, BC, V6T 1Z2, Canada
Keywords: Bayesian ; clustering ; single nucleotide polymorphisms
Abstract:

The TaqMan assay is a popular high-throughput genotyping technology for SNPs (single nucleotide polymorphisms). Clusters of genotypes are often identified by algorithms applied to normalized 2-dimensional data. We are investigating working with un-normalized data and model-based approaches. Methods based on clusters around lines seem appropriate by looking at the data. We use a Bayesian approach to incorporate prior information about the lines locations. This work is joint with Professors William Welch and Ruben Zamar.

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