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Activity Number: 72
Type: Contributed
Date/Time: Sunday, August 6, 2006 : 4:00 PM to 5:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #306483
Title: Note on Randomization-Based Inferences for Randomized Clinical Trials
Author(s): Guohua Pan*+ and Yibin Wang
Companies: Johnson & Johnson Pharmaceutical R&D and Novartis Pharmaceuticals Corporation
Address: 1125 Trenton-Harbourton Road, Titusville, NJ, 08560,
Keywords:
Abstract:

In many randomized clinical trials, study subjects represent a non-random convenience sample of available subjects from a perceived target population. However, random sampling based statistical methods are frequently used in analyzing these randomized available case studies. For this type of studies, randomization tests have been proposed in the literature as replacements of or alternatives to sampling based methods. Compared with sampling based methods, randomization based methods differ in several aspects. This paper further discusses and contrasts sampling and randomization based inferences for analyzing randomized clinical trials.

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