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Activity Number: 210
Type: Contributed
Date/Time: Monday, August 7, 2006 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #306479
Title: Favorite Datasets from Early Phases of Drug Research: Part 6
Author(s): Thomas E. Bradstreet and Thomas H. Short*+
Companies: Merck Research Laboratories and Indiana University of Pennsylvania
Address: IUP Mathematics Department, Indiana, PA, 15705,
Keywords: statistics education ; standard data sets ; data analysis
Abstract:

We present small to moderate sized data sets to be used for classroom demonstrations, workshops, homework problems, projects, and exam questions. The data sets can also serve as standards in research comparisons of new and existing statistical methodologies. These data sets illustrate topics and issues including bioequivalence, dose proportionality, dose response, special target populations (such as the elderly and gender groups), blocking factors, interaction, non-normality, heteroscedasticity, concordant and discordant outliers, repeated measures for longitudinal data, unequal sequence effects in crossover trials, multiplicity, and residual analysis. The data sets originate from Preclinical (animal) and Phase I Clinical Pharmacology (human) studies in drug research. These and other pedagogically useful data sets are located at www.math.iup.edu/~tshort/Bradstreet/.

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