JSM Preliminary Online Program
This is the preliminary program for the 2006 Joint Statistical Meetings in Seattle, Washington.

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Activity Number: 381
Type: Contributed
Date/Time: Wednesday, August 9, 2006 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract - #306426
Title: On Analysis of Time to Progression
Author(s): Zhiping Sun*+ and Cong Chen
Companies: Merck & Co., Inc. and Merck & Co., Inc.
Address: 608 Elmway Circle, Blue Bell, PA, 19422,
Keywords: time to progression ; survival ; surrogate
Abstract:

Time to (disease) progression serves as a critical intermediate endpoint to survival. With unprecedented number of new oncology therapies being tested, the role of time to progression in oncology drug development is becoming increasingly important. In this presentation, statistical issues will be discussed when time to progression is considered as a clinical endpoint, a time-dependent covariate, or an intermediate endpoint to survival in clinical trials which have a primary objective of demonstrating superiority of a new therapy versus a comparator timely and reliably. Relevant clinical design issues will also be discussed.

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Revised April, 2006