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Activity Number:
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528
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Type:
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Topic Contributed
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Date/Time:
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Thursday, August 10, 2006 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #306295 |
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Title:
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Gender by Treatment Interaction on Coronary Lesion Revascularization in Drug-Eluting Stent Trials
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Author(s):
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Zheng Zhou*+ and Liang Li and Hong Wang
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Companies:
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Boston Scientific Corporation and Boston Scientific Corporation and Boston Scientific Corporation
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Address:
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1 Boston Scientific Place, Natick, MA, 01760,
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Keywords:
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treatment-by-gender interaction ; logistic regression ; drug-eluting stent
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Abstract:
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The use of drug-eluting stents has reduced target lesion revascularization (TLR) after coronary angioplasty significantly. It has been of clinical interest whether there is a "gender effect" in outcomes associated with this treatment. Using data from large-scale randomized trials of drug-eluting stent, the magnitude of treatment effect of drug-eluting stent versus bare-metal stent was examined in men and women. Multiple logistic regression models were used to analyze gender by treatment interaction with and without controlling for patient baseline and lesion characteristics. The results showed that after adjustment, there was no significant difference in treatment outcomes between the groups. Men and women appeared to enjoy equally the clinical benefit associated with drug-eluting stent treatment.
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