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Activity Number:
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118
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Type:
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Contributed
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Date/Time:
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Monday, August 7, 2006 : 8:30 AM to 10:20 AM
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Sponsor:
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Section on Quality and Productivity
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| Abstract - #306241 |
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Title:
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Statistical Monitoring of Heteroscedastic Dose-Response Profiles from High-Throughput Screening
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Author(s):
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James D. Williams*+ and Jeffrey B. Birch and William H. Woodall and Nancy Ferry
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Companies:
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GE Global Research and Virginia Polytechnic Institute and State University and Virginia Polytechnic Institute and State University and DuPont Crop Protection
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Address:
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1 Research Circle, Niskayuna, NY, 12309,
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Keywords:
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bioassay ; control chart ; lack-of-fit ; multivariate SPC
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Abstract:
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In agricultural crop product discovery, in vivo bioassay experiments are used to identify promising compounds for further research. A replicated dose-response of commercial crop protection products is assayed and used to monitor the bioassay quality. The activity of these compounds on the test organisms is characterized by a dose-response curve measured from the bioassay. If undesirable conditions in the bioassay arise then a bioassay monitoring procedure is needed to quickly detect such issues. In this paper we illustrate a proposed nonlinear profile monitoring method to monitor the variability of multiple assays, the adequacy of the dose-response model chosen, and the estimated dose-response curves for aberrant cases in the presence of heteroscedasticity. We illustrate these methods with in vivo bioassay data collected over one year from DuPont Crop Protection.
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