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Activity Number:
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71
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Type:
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Contributed
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Date/Time:
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Sunday, August 6, 2006 : 4:00 PM to 5:50 PM
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Sponsor:
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IMS
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| Abstract - #306186 |
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Title:
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Identifiably of Placebo Responders via Potential Outcomes
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Author(s):
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Eva Petkova*+ and Thaddeus Tarpey and Yimeng Lu and Donald Klein
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Companies:
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Columbia University and Wright State University and Columbia University and Columbia University
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Address:
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, , ,
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Keywords:
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antidepressant treatment ; biomarker ; latent class model ; randomized experiments
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Abstract:
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An important problem in the clinical practice and research on mental health and control of pain is identifying and differentiating placebo from a true drug effect. Two types for medical studies can be distinguished for their utility for addressing this problem. Acute treatment studies randomize ill subjects to either drug or placebo. Treatment discontinuation studies randomize subjects who improve after acute treatment to ether continuing treatment with drug, or switching to placebo. Using the potential outcomes framework we discuss what effects are identifiable with information from these two study types. Conditions ensuring identifiability are explicitly stated. Data from an acute treatment and a treatment discontinuation trial for depression are used to motivate and illustrate the discussion.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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