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Activity Number:
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546
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Type:
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Contributed
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Date/Time:
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Thursday, August 10, 2006 : 10:30 AM to 12:20 PM
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Sponsor:
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Biometrics Section
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| Abstract - #306175 |
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Title:
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The Combined p-value for Detecting Differentially Expressed Genes from High Density Oligonucleotide Arrays
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Author(s):
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Ann Hess*+ and Hari Iyer
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Companies:
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Colorado State University and Colorado State University
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Address:
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Department of Statistics, Fort Collins, CO, 80523,
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Keywords:
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microarrays ; differential gene expression
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Abstract:
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Currently, most tests of differential expression are performed using expression summary values representing each probe set on a microarray. We propose using Fisher's combined p-value method to combine probe level tests of significance. The combined p method and other competing methods were compared using three spike-in data sets where the differentially expressed genes are known. Based on power and false discovery rates computed for the spike-in data sets, we demonstrate that the combined p method performs well. In addition, probe level tests allow us to develop useful diagnostic procedures for exploratory analysis of microarray data.
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- Authors who are presenting talks have a * after their name.
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