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Activity Number:
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152
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Type:
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Contributed
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Date/Time:
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Monday, August 7, 2006 : 10:30 AM to 12:20 PM
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Sponsor:
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Biometrics Section
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| Abstract - #306104 |
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Title:
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Simultaneous Inference for Semiparametric Nonlinear Mixed-effects Models with Covariate Measurement Errors and Missing Responses
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Author(s):
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Wei Liu*+ and Lang Wu
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Companies:
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The University of British Columbia and The University of British Columbia
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Address:
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333-6356 Agricultural Road, Vancouver, BC, V6T 1Z2, Canada
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Keywords:
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cubic spline basis ; longitudinal data ; Monte Carlo EM algorithm ; random effects model
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Abstract:
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Semiparametric nonlinear mixed-effects (NLME) models are flexible for modeling complex longitudinal data. Covariates are usually introduced in the models to partially explain inter-individual variations. Some covariates, however, may be measured with substantial errors. Moreover, the responses may be missing and the missingness may be nonignorable. We propose two approximate likelihood methods for semiparametric NLME models with covariate measurement errors and nonignorable missing responses. The methods are illustrated in a real data example. Simulation results show that both methods perform well and are much better than the commonly used naive method.
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