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Activity Number:
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381
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Type:
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Contributed
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Date/Time:
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Wednesday, August 9, 2006 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #306006 |
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Title:
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Testing for Change-Points in Waiting Time Distributions
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Author(s):
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Thomas Hammerstrom*+ and Rafia Bhore
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Companies:
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U.S. Food and Drug Administration and U.S. Food and Drug Administration
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Address:
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12111 Willow Wood Drive, Silver Spring, MD, 20904,
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Keywords:
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changepoint ; piecewise exponential ; bootstrap
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Abstract:
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This paper will present the results of some simulations on fitting and estimating parameters of piece-wise exponential (PWE) models for time to event data. It will focus on two particular problems: 1) the accuracy of the likelihood ratio in choosing the correct distribution for the times among exponential, PWE with one change-point, PWE with two change-points, and Weibull; 2) comparison of true and nominal coverage levels of confidence intervals for parameters computed by bootstrap and parametric methods. Results will include data with and without time varying covariates.
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