JSM Preliminary Online Program
This is the preliminary program for the 2006 Joint Statistical Meetings in Seattle, Washington.

The views expressed here are those of the individual authors
and not necessarily those of the ASA or its board, officers, or staff.

Back to main JSM 2006 Program page

Activity Number: 187
Type: Topic Contributed
Date/Time: Monday, August 7, 2006 : 2:00 PM to 3:50 PM
Sponsor: Section on Bayesian Statistical Science
Abstract - #305846
Title: A Tiered Treatment Design for a Historically Controlled Medical Device Clinical Trial
Author(s): Alistair O'Malley*+
Companies: Harvard Medical School
Address: Department of Health Care Policy, Boston, MA, 02115-5899,
Keywords: Bayesian analysis ; coronary-artery stents ; historical control ; hierarchical modeling ; medical devices ; tiered treatment design
Abstract:

I will describe a novel design for a single-armed trial of a new drug-coated coronary-artery stent. In order to make comparisons against coronary artery bypass graft (CABG) surgery, two historical trials involving a third treatment (bare metal stenting) are used. One of the historical trials compares the drug-coated stent to bare metal stenting, while the other compares bare metal stenting to CABG. I will discuss the advantages and disadvantages of the "tiered treatment design" and present the results from the analysis of the trial. In particular, I will demonstrate that, in this case, the tiered treatment design leads to a different conclusion than the standard historical-control analysis.

  • The address information is for the authors that have a + after their name.
  • Authors who are presenting talks have a * after their name.

Back to the full JSM 2006 program

JSM 2006 For information, contact jsm@amstat.org or phone (888) 231-3473. If you have questions about the Continuing Education program, please contact the Education Department.
Revised April, 2006