|
Activity Number:
|
75
|
|
Type:
|
Contributed
|
|
Date/Time:
|
Sunday, August 6, 2006 : 4:00 PM to 5:50 PM
|
|
Sponsor:
|
Biopharmaceutical Section
|
| Abstract - #305702 |
|
Title:
|
Exploring the Relationship between Extended Oral Anticoagulant Therapy after a First Episode of Venous Thrombosis and Mortality Using Meta-analysis
|
|
Author(s):
|
Brianna Miller*+
|
|
Companies:
|
The University of Oklahoma
|
|
Address:
|
500 W. Main Street, Oklahoma City, OK, 73102,
|
|
Keywords:
|
meta-analysis ; venous thrombosis ; anticoagulant therapy ; mortality
|
|
Abstract:
|
The primary endpoint of studies examining the effect of extended oral anticoagulant therapy on recurrent venous thromboembolism after a first episode of venous thrombosis is recurrence, while the secondary endpoints are mortality and major bleeding. This study examines the relationship between extended oral anticoagulant therapy after a first episode of venous thrombosis and mortality using meta-analysis. Results from seven articles were examined for inclusion. Odds ratios and 95% CIs for the relationship between mortality and extended therapy were estimated. ORs were combined using the Mantel-Haenszel method. A dot plot displays ORs with 95% CIs for each study. A chi-square heterogeneity statistic for the ORs is shown. Combinability of studies based on independence, patient population, and study design and conclusions about the main relationship are discussed.
|
