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Activity Number:
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547
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Type:
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Contributed
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Date/Time:
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Thursday, August 10, 2006 : 10:30 AM to 12:20 PM
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Sponsor:
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Biometrics Section
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| Abstract - #305601 |
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Title:
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Missing Genotypes in TDT
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Author(s):
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Gulhan Alpargu*+
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Companies:
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California State University, Fullerton
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Address:
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CSUF Mathematics Department, Fullerton, CA, 92834,
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Keywords:
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missing genotype ; Mendelian inheritance ; linkage disequilibrium ; TDT
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Abstract:
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Transmission disequilibrium test (TDT) attempts to detect markers in linkage disequilibrium with a disease in the presence of association. TDT uses complete genotype information from trios. Genotyping errors or disease with late onset may cause missing genotypes. It is common to exclude families when at least one of the genotypes is missing. Several approaches have been proposed to handle missing genotypes of parents, but not much attention has been given to that of children. We present a robust TDT (rTDT) that handles missing genotypes on any trios. The rTDT produces minimum and maximum values of the TDT statistics, consistent with all possible completions of the missing data. We apply rTDT to identify markers of susceptibility to Crohn disease. We show that only two of the 11 markers originally associated to phenotype do not depend on the assumptions about the missing data mechanism.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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