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Activity Number: 141
Type: Contributed
Date/Time: Monday, August 7, 2006 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section
Abstract - #305523
Title: On Estimating Treatment Effects under Noncompliance in Randomized Clinical Trials
Author(s): Heejung Bang*+ and Clarence E. Davis
Companies: Cornell University and The University of North Carolina at Chapel Hill
Address: 411 E. 69th Street, New York NY, NY, 10021,
Keywords: as treated ; instrumental variables ; intention-to-treat ; noncompliance ; per-protocol
Abstract:

In this report, we compared four estimators---intention-to-treat (ITT), as treated (AT), per-protocol (PP), and instrumental variables (IV) estimators---considered conventionally for treatment effect estimation by simulation under different noncompliance scenarios in typical clinical trial settings. We found that ITT and IV estimators are not perfect and can be problematic, although they carry desirable properties.

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