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Activity Number: 430
Type: Luncheons
Date/Time: Wednesday, August 9, 2006 : 12:30 PM to 1:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #305514
Title: Use of Propensity Scoring in Clinical Trials
Author(s): Daniel P. Reyner*+
Companies: Zimmer, Inc.
Address: Clinical Affairs, Warsaw, IN, 46581,
Keywords: propensity scoring ; clinical trials ; bias
Abstract:

Prior to analysis of clinical endpoints, the trial statistician may encounter significant and clinically meaningful between-group differences in distributions of potentially influential baseline and demographic characteristics. Such differences elevate concern of biased estimates of treatment effects. Examples may include studies with significant losses over follow-up, interim analyses, and post-approval studies. Discussion will focus on the use of propensity scoring in such situations, as well as various types of propensity scoring methods and related features.


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Revised April, 2006