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Activity Number: 72
Type: Contributed
Date/Time: Sunday, August 6, 2006 : 4:00 PM to 5:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #305503
Title: Interval Estimation of Risk Ratio in the Simple Compliance Randomized Trial
Author(s): Kung-Jong Lui*+
Companies: San Diego State University
Address: Department of Mathematics and Statistics, San Diego, CA, 92182-7720,
Keywords: efficiency ; simple compliance trial ; efficacy ; risk ratio ; coverage probability
Abstract:

Consider the simple compliance randomized trial (SCRT) in which patients assigned to an experimental group may switch to receive a control treatment, but patients assigned to a control group are assumed to receive their assigned treatment. Five asymptotic interval estimators for the relative risk (RR) of probabilities of response among patients who would comply with the experimental treatment under the SCRT are developed. Monte Carlo simulations are employed to evaluate the performance of these interval estimators in a variety of situations. A systematic discussion on comparisons and findings is included.

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Revised April, 2006