JSM Preliminary Online Program
This is the preliminary program for the 2006 Joint Statistical Meetings in Seattle, Washington.

The views expressed here are those of the individual authors
and not necessarily those of the ASA or its board, officers, or staff.

Back to main JSM 2006 Program page

Activity Number: 517
Type: Contributed
Date/Time: Thursday, August 10, 2006 : 8:30 AM to 10:20 AM
Sponsor: Biometrics Section
Abstract - #305452
Title: Hypothesis Testing of Treatment Policies in Two-Stage Randomization Designs in Clinical Trials
Author(s): Xiang Guo*+ and Anastasios A. Tsiatis
Companies: sanofi-aventis and North Carolina State University
Address: 35 River Drive, S., Jersey City, NJ, 07310,
Keywords: counting process ; induction therapy ; inverse weighting ; maintenance therapy ; potential outcomes ; outcomes
Abstract:

In many clinical trials related to diseases such as cancers and HIV, patients are treated by different combinations of therapies. This leads to two-stage designs, where patients are randomized initially to a primary therapy and then, depending on the disease remission and patients consent, a maintenance therapy is assigned randomly. In this paper, we propose a method for hypothesis testing of treatment policies in such two-stage studies with right censoring by using a weighted version of log-rank test. The method is demonstrated through simulations.

  • The address information is for the authors that have a + after their name.
  • Authors who are presenting talks have a * after their name.

Back to the full JSM 2006 program

JSM 2006 For information, contact jsm@amstat.org or phone (888) 231-3473. If you have questions about the Continuing Education program, please contact the Education Department.
Revised April, 2006