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Activity Number:
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547
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Type:
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Contributed
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Date/Time:
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Thursday, August 10, 2006 : 10:30 AM to 12:20 PM
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Sponsor:
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Biometrics Section
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| Abstract - #305436 |
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Title:
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Testing Hardy-Weinberg Equilibrium for Loci on the X Chromosome
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Author(s):
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Gang Zheng+ and Jungnam Joo* and Chun Zhang and Nancy L. Geller
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Companies:
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National Heart, Lung, and Blood Institute and National Institutes of Health and Roche Palo Alto LLC and National Heart, Lung, and Blood Institute
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Address:
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6701 Rockledge Drive, Bethesda, MD, 20892,
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Keywords:
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Fisher's combination ; HWE ; SNP ; sex-linked genes
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Abstract:
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Testing Hardy-Weinberg equilibrium (HWE) is an important step in quality control before genetic data analysis. With 100,000 or more single-nucleotide polymorphisms (SNPs) available for association studies, thousands come from the X chromosome. To study these sex-linked SNPs, testing departure from HWE is important not only for quality control but for determining whether an allele-based analysis is valid. Many statistical methods for testing HWE for loci on autosomal chromosomes have been discussed. For males, a marker on the X chromosome has only one allele. Testing HWE using females is usually less powerful. We will discuss HWE test for loci on the X chromosome.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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