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Activity Number:
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75
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Type:
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Contributed
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Date/Time:
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Sunday, August 6, 2006 : 4:00 PM to 5:50 PM
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Sponsor:
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Biometrics Section
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| Abstract - #305415 |
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Title:
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Examining the Effect of Biomarkers in Terms of Pathological Compartmentalization and a Continuous Variable
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Author(s):
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Irene Helenowski*+ and Edward F. Vonesh and Ryan J. Deaton and Borko Jovanovic and Alfred W. Rademaker and Sally A. Freels and Vijayalakshmi Ananthanarayanan and Peter H. Gann
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Companies:
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Northwestern University and Baxter Healthcare Corporation and University of Illinois at Chicago and Northwestern University and Northwestern University and University of Illinois and University of Illinois at Chicago and University of Illinois at Chicago
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Address:
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680 N. Lake Shore Drive, Chicago, IL, 60611,
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Keywords:
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biomarkers ; pathological compartmentalization ; continuous variables ; regression
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Abstract:
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In studying biomarkers associated with carcinogenesis, we need to examine the spatial-temporal mechanisms involved. Do biomarker levels follow a gradient related to distance from the cancer region? What model and covariance structure best fit the data? This work stems from previous work concerning the effects of a continuous variable, namely distance, on biomarker reproducibility (Helenowski et al. 2005). Those studies focused on the effects of a continuous variable on reproducibility solely in the normal tissue compartment. We now examine the effects of a continuous variable, adjusting for pathological compartmentalization on associations between biomarker samples based on least square differences. Future studies will involve examining reproducibility in terms of these two factors. We apply our methods to MCM2 index values coming from the prostate gland.
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