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Abstract:
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We have analyzed microarray datasets from a cross-species melanoma study in which progressively metastatic melanomas were induced experimentally from a nonmetastatic human melanoma cell line and a mouse melanoma line by repeatedly selecting cells with the greatest metastatic potential. We performed homology search, LPE testing, and integrative correlation analyses to discover cross-species co-regulation patterns. We found these analyses resulted in many co-regulated genes between the two microarray datasets, implying that highly concordant gene regulation networks of melanoma metastasis are present between human and mouse. This cross-species investigation provided a number of interesting gene sub-clusters, including ones reported in the original study.
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