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Activity Number:
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1
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Type:
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Other
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Date/Time:
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Sunday, August 6, 2006 : 2:00 PM to 3:50 PM
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Sponsor:
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The ASA
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| Abstract - #305242 |
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Title:
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Statistical Analysis of Haplotype-Disease Association
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Author(s):
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Danyu Lin*+
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Companies:
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The University of North Carolina at Chapel Hill
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Address:
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3101E McGavran-Greenberg Building, CB#7420, Chapel Hill, NC, 27599-7420,
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Keywords:
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association studies ; case-control studies ; EM algorithm ; maximum likelihood ; missing data ; SNPS
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Abstract:
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A haplotype is a specific sequence of nucleotides on a single chromosome. The associations between haplotypes and disease phenotypes provide critical information about the genetic basis of complex human diseases. Only the combination of the two haplotypes is directly observable on an individual. In this lecture, we describe various statistical methods for inferring haplotype-phenotype associations. We consider all commonly used study designs, including cross-sectional, case-control and cohort studies, as well as family-based studies. The phenotype can be a disease indicator, a quantitative trait or a potentially censored time to disease variable. Both candidate-gene studies and genomewide scans will be discussed. Illustrations with real studies will be provided. There will also be software demonstration.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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