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Activity Number:
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395
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Type:
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Invited
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Date/Time:
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Wednesday, August 9, 2006 : 10:30 AM to 12:20 PM
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Sponsor:
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ENAR
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| Abstract - #305215 |
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Title:
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Latent Class Measurement of Frailty and Dysregulation in Older Adults
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Author(s):
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Karen Bandeen-Roche*+
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Companies:
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Johns Hopkins Bloomberg School of Public Health
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Address:
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Department of Biostatistics, JHBSPH, Baltimore, MD, 21205-2179,
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Keywords:
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construct ; validity ; conditional independence ; aging ; prediction ; constraint
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Abstract:
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Frailty is a health state that geriatricians assert as recognizable, but has proven illusive to classify rigorously. It has no gold standard, thus classification must be driven by theory on the underpinnings and clinical presentation of the syndrome. This paper proposes methodology for the measurement of frailty and related states of dysregulation that integrates latent class modeling of the data with the biological theory, hence primarily targeting internal validity. Utility of latent class modeling is evaluated and compared side by side with methods that invoke fewer distributional assumptions and are focused primarily on predictive validity. Measurement strategies that counterbalance the two strategies are proposed, evaluated, and illustrated. The paper aims to improve methodology for the measurement of syndromes lacking a gold standard.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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