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Activity Number: 525
Type: Invited
Date/Time: Thursday, August 10, 2006 : 10:30 AM to 12:20 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #305162
Title: Diversity of Haplotype Configurations in the Human Genome: Implications for Genome-Wide Association Studies
Author(s): Shuying S. Li*+
Companies: Fred Hutchinson Cancer Research Center
Address: 1100 Fairview Ave., N., Seattle, WA, 98109,
Keywords:
Abstract:

The International HapMap Consortium and Perlegen, Inc., independently completed more than 1 million SNP genotypes on individuals with African, European, and Asian ancestors. The availability of both sources of genotype data allows the research community to investigate aspects of human genome variations and aim to genome-wide association studies. In this talk, our focus is on assessing diversity of haplotype configurations among African, European, and Asian populations. Using the chi-square test, we tested the significance of the diversity. The diversity of haplotype configuration in the human genome will implicate the study design and analysis planning in future association studies of human populations, especially in admixture population association studies. We hope our method and results will provide guidance for those studies' design and analysis planning.


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