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Activity Number: 3
Type: Invited
Date/Time: Sunday, August 6, 2006 : 2:00 PM to 3:50 PM
Sponsor: WNAR
Abstract - #305154
Title: A Bayesian Seamless Design
Author(s): Lurdes Y. T. Inoue*+
Companies: University of Washington
Address: F600 Health Sciences Building, Seattle, WA, 98195-7232,
Keywords: Bayesian sequential design ; clinical trials ; mixture models ; seamless designs
Abstract:

In this talk, we present a seamless phase II/III Bayesian design for comparative clinical trials. The design is based on both survival time and discrete early events related to survival through a mixture model. We discuss simulation studies in the context of a nonsmall cell lung cancer trial and compare operating characteristics of our proposed design to conventional group-sequential phase III designs.


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