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Activity Number:
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525
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Type:
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Invited
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Date/Time:
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Thursday, August 10, 2006 : 10:30 AM to 12:20 PM
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Sponsor:
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Section on Statistics in Epidemiology
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| Abstract - #305145 |
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Title:
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Candidate Gene Association Studies: Power and Sample Size Requirements
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Author(s):
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Bingshu E. Chen*+ and Philip S. Rosenberg
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Companies:
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National Cancer Institute and National Cancer Institute
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Address:
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6120 Executive Blvd., Room 8033, Rockville, MD, 20852,
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Keywords:
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case control study ; genetic epidemiology ; haplotype frequency test ; power and sample size ; single nucleotide polymorphisms
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Abstract:
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Power and sample size requirements are a critical design issue in genetic case control association studies. This problem is complicated by correlations among nearby SNPs (LD), and different statistical methods are available to test for association (i.e., SNP-based tests that adjust for multiple comparisons and haplotype frequency tests). In this study, we propose guidelines for power and sample size using the omnibus test that combines the min P test for SNP analysis and the 'directed' haplotype frequency test; the former is sensitive to scenarios where disease susceptibility is conferred by a SNP and the latter to scenarios where disease susceptibility is conferred by a common haplotype. In simulation studies to determine guidelines, we incorporate empirical LD patterns of SNPs and SNP haplotypes using genetic data on candidate genes obtained by the International HapMap Project.
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