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Activity Number:
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261
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Type:
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Invited
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Date/Time:
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Tuesday, August 8, 2006 : 10:30 AM to 12:20 PM
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Sponsor:
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Section on Health Policy Statistics
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| Abstract - #305053 |
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Title:
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Exploring the Relationship between Adverse Events, Compliance, Dropout, and Abstinence in Pharmacotherapy Smoking Cessation Trials
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Author(s):
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Joel A. Dubin*+
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Companies:
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University of Waterloo
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Address:
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, Waterloo, ON, , Canada
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Keywords:
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abstinence success ; compliance ; dose-ranging ; graphical methods ; safety data ; survival models
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Abstract:
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In trials of pharmacological aids to smoking cessation, the participants who comply (both not dropping out and adhering to their prescribed medication regimen) tend to exhibit higher rates of abstinence. Here, we apply specialized survival graphical methods to reveal this trend and subsequently implement complex survival modeling to identify predictors of dropout and overall noncompliance, including consideration of medication dosage strength, the experiencing and severity of adverse events, and abstinence success. We apply the methods to a dose-ranging clinical trial of naltrexone, combined with nicotine patch, where the study population was comprised of 400 current smokers who desired abstinence.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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