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Activity Number:
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84
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Type:
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Invited
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Date/Time:
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Monday, August 7, 2006 : 8:30 AM to 10:20 AM
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Sponsor:
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Chance
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| Abstract - #305012 |
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Title:
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Information Processing in Cellular Networks
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Author(s):
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Ravi Iyengar*+ and Avi Ma'ayan
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Companies:
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Mount Sinai School of Medicine
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Address:
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Department of Pharmacology, Box 1215, New York, NY, 10029,
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Keywords:
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cell signaling ; network dynamics ; regulatory motifs ; information processing
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Abstract:
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Information processing in mammalian cells occurs by interactions between cellular components that form a coupled-chemical-reaction network that has substantial information processing ability. To study this, we developed a network of 545 components and 1,259 interactions representing signaling pathways and cellular machines in a neuron. Using graph theory, we analyzed signal flow induced by receptor activation. Networking resulted in the emergence of regulatory motifs (feedback and feedforward loops and bifans) that process information. Key regulators of neuronal plasticity are highly connected nodes and required for formation of the motifs, suggesting these emergent regulatory motifs may be important for choosing between homeostasis and plasticity.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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