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Abstract:
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There is currently considerable interest in the augmentation of existing oral health studies by addition of a genetic component. These extant studies frequently reflect such traditional designs as clinical trials, case-control studies, and longitudinal epidemiologic investigations. In this talk, a number of special considerations associated with the design and analysis of such extensions are addressed and several paradigms for addressing genetic research hypotheses are explored, including those for assessment of gene-gene and gene-environment interactions. Models to address concerns related to bias of ascertainment are presented. These are illustrated using examples from ongoing efforts in areas such as periodontology, enamel defects, and caries research.
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