JSM 2005 Online Program

Abstract #304795

This is the preliminary program for the 2005 Joint Statistical Meetings in Minneapolis, Minnesota. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2005); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

To View the Program:
You may choose to view all activities of the program or just parts of it at any one time. All activities are arranged by date and time.

The views expressed here are those of the individual authors
and not necessarily those of the ASA or its board, officers, or staff.

The Program has labeled the meeting rooms with "letters" preceding the name of the room, designating in which facility the room is located:

Minneapolis Convention Center = “MCC” Hilton Minneapolis Hotel = “H” Hyatt Regency Minneapolis = “HY”

Back to main JSM 2005 Program page

Legend:

= Applied Session,

= Theme Session,

= Presenter

Activity Number:	237
Type:	Contributed
Date/Time:	Tuesday, August 9, 2005 : 8:30 AM to 10:20 AM
Sponsor:	Section on Statistics in Epidemiology
Abstract - #304795
Title:	Comprehensive Evaluation of Breast and Ovarian Cancer Risks
Author(s):	Sining Chen*+
Companies:	Johns Hopkins School of Medicine
Address:	550 N Broadway, Baltimore, MD, 21205, United States
Keywords:	Retrospective likelihood ; multiplicative hazards ; breast cancer
Abstract:	The screening and clinical management of families carrying deleterious germline mutations of the BRCA1 and BRCA2 genes relies on an accurate evaluation of the age-specific risk of developing cancer of the breast and the ovaries. In this paper, we provided a comprehensive evaluation of such risk, tailored to the U.S. population. We combined the results of a metaanalysis of published studies with a large-scale, multicenter retrospective analysis of 1,984 tested fa milies (676 of which are of Ashkenazi Jewish descent) assembled through the Cancer Genetics Network. We found a significant difference in the cumulative risk of breast cancer at younger ages between Ashkenazi Jewish and other carriers. For both groups, the combined risk estimates were lower than those arising from the metaanalysis alone. In the nonAshkenazi Jewish population, the estimated breast cancer penetrances at age 70 were 0.48 (95\% CI 0.41--0.56) in BRCA1 carriers and 0.43 (0.38--0.49) in BRCA2 carriers, while ovarian cancer penetrances at age 70 were 0.41 (0.33--0.51) in BRCA1 carriers and 0.16 (0.11--0.23) in BRCA2 carriers.

The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2005 program