JSM 2005 - Toronto

Abstract #304785

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Activity Number: 74
Type: Contributed
Date/Time: Sunday, August 7, 2005 : 8:00 PM to 9:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #304785
Title: Statistical Analysis of Bioassays of Environmental Toxicants Using the Nematode Caenorhabditis Elegans
Author(s): Sandra McBride*+ and Grace E. Kissling and Windy Boyd and Jon Freedman
Companies: Duke University and National Institute of Environmental Health Sciences and Duke University and Duke University
Address: NSEES Box 90238, Durham, NC, 27708, United States
Keywords: bioassay ; C. elegans ; concentration-response curves ; Hill model
Abstract:

To decrease the time and expense of current toxicity testing protocols, high throughput methods have been developed to screen neurological and developmental toxicants rapidly using the nematode Caenorhabditis elegans (C. elegans). This organism is well-suited for these studies due to its short life cycle, easy and inexpensive maintenance and culturing, and detailed biological knowledge. While previous screening was done one organism at a time under a microscope, newly available technology can analyze about 1 million C. elegans in an eight-hour day. We describe statistical issues involved in analyses of bioassays that use C. elegans to examine sublethal toxicity endpoints, including growth, reproduction, and feeding. Worms are used at a specific developmental stage for each test and for each worm, four variables are measured: length, optical density, and red and green fluorescence. Analysis of the data involves using the four variables to classify populations of worms into developmental stages, comparison of multivariate distributions for experimental with historic controls, and fitting of nonlinear concentration-response curves.

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Revised March 2005